Get away from some decent hands in a heads up pot.
Although you shouldn’t automatically give up hands like second pair in two-way pots, you might be able 
to bail out on the turn in some cases. If your opponent were to have bet the flop, and was now betting again on the turn, this would tend to signify that he would have a pretty good hand.
Thus, it would generally be correct to fold second pair at this point, especially if the other poker player were to be tight. When playing against a maniac or very loose poker player, however, you would just have to call him down and hope for the best.
Another situation in which you could probably save money by folding most of the time would be when you were to have bet the flop with top pair or an overpair, only to see a ‘scary’ card come on the turn and your opponent firing in a bet. Here are two examples:
Example 1
The board was a three, a five, and a ten and you were to bet the flop with your queen and ten. A king was to come on the turn, it would make three to a flush, and your poker rival was to bet out. Although he could be semi-bluffing, it would be very likely you were beat and drawing either slim or dead. So, you should fold and go on to the next poker hand, rather than spending two big bets trying to keep him honest.
Example 2
The board was a two, a seven, and a jack and you were to bet the flop with your pair of kings. An ace was to come on the turn and your rival was to bet out. If he were to have an ace, you would be down to two outs. And it would be possible that he would, as that is the card most frequently played in holdem poker.
Also, your rival wouldn’t be any more likely than you would to like that card if it wouldn’t help him (thus less apt to be betting without an ace). It would hurt to throw away kings, but you would be almost always correct in doing so in this case. Only against poker players who play with a good deal of trickery and ingenuity would calling be the best option.
What to do when faced with calling a bet with less than top pair.
Although touched upon in the preceding tip, this will be an important and common enough circumstance 
to merit further remarks. Here are three points that will help steer your decision:
How Does Your Opponent Play?
You could call with a much weaker hand against a very aggressive poker player. This type of poker player would bluff repeatedly, and it would often be a mistake to fold any pair against him. He would just have to show you the best hand. Pay attention to your opponents.
Against a poker player who would generally be very tight or passive, however, it would be a pretty safe bet that you were beaten, so you could confidently fold. In fact, you might even consider folding top pair with a trivial kicker against someone who was extremely tight.
What Is the Texture of the Board?
On a board such as a pair of twos, a seven, and a queen, it is highly unlikely that your poker rival will bet both the flop and turn without at least a pair. There aren’t any draws present, and your call on the flop notified him that you have some kind of poker hand.
Though, if the board shows a four, a five, a nine, and a ten (and two of the cards are the same suit), it is quite likely that a hand like an ace and a nine is good at this point. Your poker rival might have a ten or a nine with a worse kicker, or be semi-bluffing with a straight or flush draw. You should be more disposed to call your rival down with second pair when numerous logical draws are present on the board.
What Is the Pot Size?
You shouldn’t make the mistake of folding too quickly when the pot would be large. A bad call would cost you one or two bets, but a bad fold would cost you all the bets in the pot, so it would be far better to slip up on the side of calling if you were to be unsure about your hand.
That said, the pot pay will have reached its present size because your poker rival would have been pushing a good hand, so you wouldn’t need to always pay off with a subsidiary second pair type of hand simply because the pot would have grown large.
Mistakes in Judgment
You shouldn’t be dispirited if you have made some mistakes in judgment in these types of situations. It would take a great deal of experience to make consistently correct decisions, and even the best holdem poker players will make sporadic mistakes. Poker Fundamentals.
If you were to remember to consider your poker opponent, the board, and the size of the pot, you would have a good structure for making the right choice, tough. On those times when you have still been turn between calling and folding, however, remember that calling with a loser would be a small mistake, but folding to a winner would be a big one.